Ontology highlight
ABSTRACT:
SUBMITTER: Coffey LL
PROVIDER: S-EPMC6010452 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Coffey Lark L LL Keesler Rebekah I RI Pesavento Patricia A PA Woolard Kevin K Singapuri Anil A Watanabe Jennifer J Cruzen Christina C Christe Kari L KL Usachenko Jodie J Yee JoAnn J Heng Victoria A VA Bliss-Moreau Eliza E Reader J Rachel JR von Morgenland Wilhelm W Gibbons Anne M AM Jackson Kenneth K Ardeshir Amir A Heimsath Holly H Permar Sallie S Senthamaraikannan Paranthaman P Presicce Pietro P Kallapur Suhas G SG Linnen Jeffrey M JM Gao Kui K Orr Robert R MacGill Tracy T McClure Michelle M McFarland Richard R Morrison John H JH Van Rompay Koen K A KKA
Nature communications 20180620 1
Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. The GD41-inoculated animal, experiencing fetal death ...[more]