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History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.


ABSTRACT: OBJECTIVE:We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. METHODS:We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis. RESULTS:History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36-4.09; z?=?3.07, p?

SUBMITTER: Diniz BS 

PROVIDER: S-EPMC5365367 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis.

Diniz Breno S BS   Teixeira Antonio L AL   Cao Fei F   Gildengers Ariel A   Soares Jair C JC   Butters Meryl A MA   Reynolds Charles F CF  

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20170104 4


<h4>Objective</h4>We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia.<h4>Methods</h4>We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis.<h4>Results</h4>History of BD significantly increased the risk of diagno  ...[more]

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