PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.
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ABSTRACT:
SUBMITTER: Scruggs SB
PROVIDER: S-EPMC5366072 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.
Scruggs Sarah B SB Wang Ding D Ping Peipei P
Gene 20160613 1
Protein kinase C-epsilon (PKCε) is an isoform of a large PKC family of enzymes that has a variety of functions in different cell types. Here we discuss two major roles of PKCε in cardiac muscle cells; specifically, its role in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as modulating cardiac cell energy production and metabolism by targeting cardiac mitochondria. The importance of PKCε action is described within the context of intracellular localization, ...[more]
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