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The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

ABSTRACT: Atypical protein kinase C (aPKC) isozymes, PKC?/? and PKC?, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into tumor-promoter or -suppressive functions. Here, we review early and more recent literature to discuss how the different tumor types, and their microenvironments, might account for the selective signaling of each aPKC isotype. This is of clinical relevance because a better understanding of the roles of these kinases is essential for the design of new anti-cancer treatments.

SUBMITTER: Reina-Campos M

PROVIDER: S-EPMC6751000 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

Reina-Campos Miguel M Diaz-Meco Maria T MT Moscat Jorge J

Cancer cell 20190829 3

Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into tumor-promoter or -suppressive functions. Here, we review early and more recent literature to discuss how the different tumor types, and their microenvironments, might account for t ...[more]

PMID: 31474570

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