Ontology highlight
ABSTRACT:
SUBMITTER: Choi YK
PROVIDER: S-EPMC5367012 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Marine drugs 20170225 3
Tuberatolide B (TTB, C<sub>27</sub>H<sub>34</sub>O₄) is a diastereomeric meroterpenoid isolated from the Korean marine algae <i>Sargassum macrocarpum</i>. However, the anticancer effects of TTB remain unknown. In this study, we demonstrate that TTB inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. To examine the mechanism by which TTB suppresses cell growth, we determined the effect of TTB on apoptosis, ROS generation, DNA damage, and signal transduction. TTB ind ...[more]