Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Z
PROVIDER: S-EPMC5367044 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jiang Zhiping Z Heinrich Frank F McGlinchey Ryan P RP Gruschus James M JM Lee Jennifer C JC
The journal of physical chemistry letters 20161209 1
Neutron reflectometry (NR) is uniquely suited for studying protein interaction with phospholipid bilayers along the bilayer normal on an angstrom scale. However, NR on its own cannot discern specific membrane-bound regions due to a lack of scattering contrast within a protein. Here we report the successful coupling of native chemical ligation (NCL) and NR to study α-synuclein (α-syn), a membrane-binding neuronal protein central in Parkinson's disease. Two α-syn variants were generated where eith ...[more]