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Stretch-grown axons retain the ability to transmit active electrical signals.

ABSTRACT: Little is known about extensive nervous system growth after axons reach their targets. Indeed, postnatal animals continue to grow, suggesting that axons are stretched to accommodate the expanding body. We have previously shown that axons can sustain stretch-growth rates reaching 1 cm/day; however, it remained unknown whether the ability to transmit active signals was maintained. Here, stretch-growth did not alter sodium channel activation, inactivation, and recovery or potassium channel activation. In addition, neurons generated normal action potentials that propagated across stretch-grown axons. Surprisingly, Na and K channel density increased due to stretch-growth, which may represent a natural response to preserve the fidelity of neuronal signaling.

SUBMITTER: Pfister BJ

PROVIDER: S-EPMC5367051 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Stretch-grown axons retain the ability to transmit active electrical signals.

Pfister Bryan J BJ Bonislawski David P DP Smith Douglas H DH Cohen Akiva S AS

FEBS letters 20060522 14

Little is known about extensive nervous system growth after axons reach their targets. Indeed, postnatal animals continue to grow, suggesting that axons are stretched to accommodate the expanding body. We have previously shown that axons can sustain stretch-growth rates reaching 1 cm/day; however, it remained unknown whether the ability to transmit active signals was maintained. Here, stretch-growth did not alter sodium channel activation, inactivation, and recovery or potassium channel activati ...[more]

PMID: 16730003

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