Ontology highlight
ABSTRACT:
SUBMITTER: Ku SY
PROVIDER: S-EPMC5367887 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170101 6320
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen the ...[more]