Ontology highlight
ABSTRACT:
SUBMITTER: Giopanou I
PROVIDER: S-EPMC5283628 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Giopanou Ioanna I Lilis Ioannis I Papaleonidopoulos Vassilios V Agalioti Theodora T Kanellakis Nikolaos I NI Spiropoulou Nikolitsa N Spella Magda M Stathopoulos Georgios T GT
Oncoimmunology 20161118 1
The lungs are ubiquitous receptacles of metastases originating from various bodily tumors. Although osteopontin (SPP1) has been associated with tumor dissemination, the role of its isoforms in lung-directed metastasis is incompletely understood. We employed syngeneic mouse models of spontaneous and induced lung-targeted metastasis in <i>C57BL/6</i> mice competent and deficient in both <i>Spp1</i> alleles. Tumor-derived osteopontin expression was modulated using either stable anti-<i>Spp1</i> RNA ...[more]