Comparison of treatment outcome using two definitions of rapid cycling in subjects with bipolar II disorder.

ABSTRACT:

Objectives

We examined differences in treatment outcome between Diagnostic and Statistical Manual Fourth Edition (DSM-IV)-defined rapid cycling and average lifetime-defined rapid cycling in subjects with bipolar II disorder. We hypothesized that, compared with the DSM-IV definition, the average lifetime definition of rapid cycling may better identify subjects with a history of more mood lability and a greater likelihood of hypomanic symptom induction during long-term treatment.

Methods

Subjects ≥18 years old with a bipolar II major depressive episode (n=129) were categorized into DSM-IV- and average lifetime-defined rapid cycling and prospectively treated with either venlafaxine or lithium monotherapy for 12 weeks. Responders (n=59) received continuation monotherapy for six

SUBMITTER: Amsterdam JD 

PROVIDER: S-EPMC5367974 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature