Ontology highlight
ABSTRACT:
SUBMITTER: Huynh KQ
PROVIDER: S-EPMC5369019 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Organic letters 20161220 1
Formal syntheses of tetracyclic terpenoids frondosin B and liphagal are described. Both synthetic routes rely on the use of platinum-catalyzed α,β-unsaturated carbene formation for the key C-C bond forming transformations. The successful route toward frondosin B utilizes a formal (4 + 3) cycloaddition, while the liphagal synthesis features the vinylogous addition of an enol nucleophile as a key step. Both synthetic routes are discussed, revealing insights into structural requirements in the cata ...[more]