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Lewis Acid Mediated Vinylogous Additions of Enol Nucleophiles into an ?,?-Unsaturated Platinum Carbene.

ABSTRACT: A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several ?-dicarbonyl compounds participate in the reaction, as do ?-nitro and ?-cyano carbonyl species. Subjecting the indole products to acidic conditions results in the formation of fused heterocycles.

SUBMITTER: Allegretti PA

PROVIDER: S-EPMC4732870 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Lewis Acid Mediated Vinylogous Additions of Enol Nucleophiles into an α,β-Unsaturated Platinum Carbene.

Allegretti Paul A PA Huynh Khoi K Ozumerzifon Tarik J TJ Ferreira Eric M EM

Organic letters 20151214 1

A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several β-dicarbonyl compounds participate in the reaction, as do α-nitro and α-cyano carbonyl species. Subjecting the indole products to acidic conditions results in the formation of fused heterocycles. ...[more]

PMID: 26652926

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