Ontology highlight
ABSTRACT:
SUBMITTER: Duncan JS
PROVIDER: S-EPMC5369242 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Duncan Jeremy S JS Stoller Michelle L ML Francl Andrew F AF Tissir Fadel F Devenport Danelle D Deans Michael R MR
Developmental biology 20170201 2
Vestibular hair cells of the inner ear are specialized receptors that detect mechanical stimuli from gravity and motion via the deflection of a polarized bundle of stereocilia located on their apical cell surfaces. The orientation of stereociliary bundles is coordinated between neighboring cells by core PCP proteins including the large adhesive G-protein coupled receptor Celsr1. We show that mice lacking Celsr1 have vestibular behavioral phenotypes including circling. In addition, we show that C ...[more]