Ontology highlight
ABSTRACT:
SUBMITTER: Williams SJ
PROVIDER: S-EPMC5371614 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Williams Samantha J SJ Abrieu Ariane A Losada Ana A
Chromosoma 20160426 2
Centromeric chromatin containing the histone H3 variant centromere protein A (CENP-A) directs kinetochore assembly through a hierarchical binding of CENPs, starting with CENP-C and CENP-T. Centromeres are also the chromosomal regions where cohesion, mediated by cohesin, is most prominently maintained in mitosis. While most cohesin dissociates from chromosome arms in prophase, Shugoshin 1 (Sgo1) prevents this process at centromeres. Centromeric localization of Sgo1 depends on histone H2A phosphor ...[more]