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Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity.


ABSTRACT: Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5372982 | biostudies-literature |

REPOSITORIES: biostudies-literature

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