Ontology highlight
ABSTRACT:
SUBMITTER: Barrera-Chimal J
PROVIDER: S-EPMC5373452 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Barrera-Chimal Jonatan J André-Grégoire Gwennan G Nguyen Dinh Cat Aurelie A Lechner Sebastian M SM Cau Jérôme J Prince Sonia S Kolkhof Peter P Loirand Gervaise G Sauzeau Vincent V Hauet Thierry T Jaisser Frédéric F
Journal of the American Society of Nephrology : JASN 20170113 4
AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In rodents, mineralocorticoid receptor (MR) antagonism prevents AKI induced by ischemia-reperfusion (IR). We investigated the specific role of vascular MR in mediating AKI induced by IR. We also assessed the protective effect of MR antagonism in IR-induced AKI in the Large White pig, a model of human AKI. In mice, MR deficiency in smooth muscle cell ...[more]