Ontology highlight
ABSTRACT:
SUBMITTER: Song W
PROVIDER: S-EPMC5373560 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Song Wei W Cheng Daojun D Hong Shangyu S Sappe Benoit B Hu Yanhui Y Wei Neil N Zhu Changqi C O'Connor Michael B MB Pissios Pavlos P Perrimon Norbert N
Cell metabolism 20170201 2
While high-caloric diet impairs insulin response to cause hyperglycemia, whether and how counter-regulatory hormones are modulated by high-caloric diet is largely unknown. We find that enhanced response of Drosophila adipokinetic hormone (AKH, the glucagon homolog) in the fat body is essential for hyperglycemia associated with a chronic high-sugar diet. We show that the activin type I receptor Baboon (Babo) autonomously increases AKH signaling without affecting insulin signaling in the fat body ...[more]