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Genomic variants at 20p11 associated with body fat mass in the European population.


ABSTRACT:

Objective

Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.

Methods

Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N?=?6,004), the Kansas City osteoporosis study (N?=?2,207), and the Omaha osteoporosis study (N?=?968).

Results

At the genome-wide significance level (??=?5.0×10-8 ), a cluster of 10 single-nucleotide polymorphisms (SNPs) at chromosomal region 20p11 that were associated with BFM (lead SNP rs2069126, P?=?1.82×10-9 , closest gene SLC24A3) was identified in 9,179 subjects. One of the top SNPs, rs6046308 (P?=?3.74×10-8 ), was found to be nominally significant for body fat percentage in another independent study (P = 0.03, N?=?75,888) and was reported to transregulate the expression of the MPZ gene at 1q23.3 (unadjusted P?=?9.78×10-6 , N?=?1,490). Differential gene expression analysis demonstrated that SLC24A3 and CFAP61 at the identified locus were differentially expressed in tissues of people with versus without obesity (P = 3.40×10-5 and 8.72×10-4 , N?=?126 and 70), implying their potential role in fat development.

Conclusions

These results may provide new insights into the biological mechanism that underlies fat-induced obesity pathology.

SUBMITTER: Pei YF 

PROVIDER: S-EPMC5373963 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

Genomic variants at 20p11 associated with body fat mass in the European population.

Pei Yu-Fang YF   Ren Hai-Gang HG   Liu Lu L   Li Xiao X   Fang Chen C   Huang Yun Y   Hu Wen-Zhu WZ   Kong Wei-Wen WW   Feng An-Ping AP   You Xin-Yi XY   Zhao Wen W   Shen Hui H   Tian Qing Q   Zhang Yong-Hong YH   Deng Hong-Wen HW   Zhang Lei L  

Obesity (Silver Spring, Md.) 20170222 4


<h4>Objective</h4>Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population.<h4>Methods</h4>Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207)  ...[more]

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