Ontology highlight
ABSTRACT:
SUBMITTER: Browning DL
PROVIDER: S-EPMC5374020 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Browning D L DL Everson E M EM Leap D J DJ Hocum J D JD Wang H H Stamatoyannopoulos G G Trobridge G D GD
Gene therapy 20161226 3
Retroviral vector-mediated stem cell gene therapy is a promising approach for the treatment of hematopoietic disorders. However, genotoxic side effects from integrated vector proviruses are a significant concern for the use of retroviral vectors in the clinic. Insulated foamy viral (FV) vectors are potentially safer retroviral vectors for hematopoietic stem cell gene therapy. We evaluated two newly identified human insulators, A1 and A2, for use in FV vectors. These insulators had moderate insul ...[more]