Ontology highlight
ABSTRACT:
SUBMITTER: Wells ML
PROVIDER: S-EPMC5376222 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wells Melissa L ML Perera Lalith L Blackshear Perry J PJ
Trends in biochemical sciences 20170114 4
RNA-binding proteins are important modulators of mRNA stability, a crucial process that determines the ultimate cellular levels of mRNAs and their encoded proteins. The tristetraprolin (TTP) family of RNA-binding proteins appeared early in the evolution of eukaryotes, and has persisted in modern eukaryotes. The domain structures and biochemical functions of family members from widely divergent lineages are remarkably similar, but their mRNA 'targets' can be very different, even in closely relate ...[more]