Ontology highlight
ABSTRACT:
SUBMITTER: Biswas J
PROVIDER: S-EPMC6768852 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Biswas Jeetayu J Patel Vivek L VL Bhaskar Varun V Chao Jeffrey A JA Singer Robert H RH Eliscovich Carolina C
Nature communications 20190930 1
The IGF2 mRNA-binding proteins (ZBP1/IMP1, IMP2, IMP3) are highly conserved post-transcriptional regulators of RNA stability, localization and translation. They play important roles in cell migration, neural development, metabolism and cancer cell survival. The knockout phenotypes of individual IMP proteins suggest that each family member regulates a unique pool of RNAs, yet evidence and an underlying mechanism for this is lacking. Here, we combine systematic evolution of ligands by exponential ...[more]