Long-acting protein drugs for the treatment of ocular diseases.
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ABSTRACT:
SUBMITTER: Ghosh JG
PROVIDER: S-EPMC5376645 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Long-acting protein drugs for the treatment of ocular diseases.
Ghosh Joy G JG Nguyen Andrew A AA Bigelow Chad E CE Poor Stephen S Qiu Yubin Y Rangaswamy Nalini N Ornberg Richard R Jackson Brittany B Mak Howard H Ezell Tucker T Kenanova Vania V de la Cruz Elisa E Carrion Ana A Etemad-Gilbertson Bijan B Caro Roxana Garcia RG Zhu Kan K George Vinney V Bai Jirong J Sharma-Nahar Radhika R Shen Siyuan S Wang Yiqin Y Subramanian Kulandayan K KK Fassbender Elizabeth E Maker Michael M Hanks Shawn S Vrouvlianis Joanna J Leehy Barrett B Long Debby D Prentiss Melissa M Kansara Viral V Jaffee Bruce B Dryja Thaddeus P TP Roguska Michael M
Nature communications 20170323
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently as every month. Here we report a method to extend the intravitreal half-life of protein drugs as an alternative to either encapsulation or chemical modifications with polymers. We combine a 97-amino-acid peptide of human origin that binds hyaluronan, ...[more]
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