Ontology highlight
ABSTRACT:
SUBMITTER: Pleniceanu O
PROVIDER: S-EPMC5376758 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Pleniceanu Oren O Shukrun Racheli R Omer Dorit D Vax Einav E Kanter Itamar I Dziedzic Klaudyna K Pode-Shakked Naomi N Mark-Daniei Michal M Pri-Chen Sara S Gnatek Yehudit Y Alfandary Hadas H Varda-Bloom Nira N Bar-Lev Dekel D DD Bollag Naomi N Shtainfeld Rachel R Armon Leah L Urbach Achia A Kalisky Tomer T Nagler Arnon A Harari-Steinberg Orit O Arbiser Jack L JL Dekel Benjamin B
EMBO molecular medicine 20170401 4
Angiomyolipoma (AML), the most common benign renal tumor, can result in severe morbidity from hemorrhage and renal failure. While mTORC1 activation is involved in its growth, mTORC1 inhibitors fail to eradicate AML, highlighting the need for new therapies. Moreover, the identity of the AML cell of origin is obscure. AML research, however, is hampered by the lack of <i>in vivo</i> models. Here, we establish a human AML-xenograft (Xn) model in mice, recapitulating AML at the histological and molec ...[more]