Ontology highlight
ABSTRACT:
SUBMITTER: Nunes-Silva S
PROVIDER: S-EPMC5376981 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nunes-Silva Sofia S Gangnard Stéphane S Vidal Marta M Vuchelen Anneleen A Dechavanne Sebastien S Chan Sherwin S Pardon Els E Steyaert Jan J Ramboarina Stephanie S Chêne Arnaud A Gamain Benoît B
Scientific reports 20141209
VAR2CSA stands today as the leading vaccine candidate aiming to protect future pregnant women living in malaria endemic areas against the severe clinical outcomes of pregnancy associated malaria (PAM). The rational design of an efficient VAR2CSA-based vaccine relies on a profound understanding of the molecular interactions associated with P. falciparum infected erythrocyte sequestration in the placenta. Following immunization of a llama with the full-length VAR2CSA recombinant protein, we have e ...[more]