Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
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ABSTRACT:
SUBMITTER: Nakane T
PROVIDER: S-EPMC5377302 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue.
Nakane Takeichiro T Masumoto Hidetoshi H Tinney Joseph P JP Yuan Fangping F Kowalski William J WJ Ye Fei F LeBlanc Amanda J AJ Sakata Ryuzo R Yamashita Jun K JK Keller Bradley B BB
Scientific reports 20170403
The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage cardiac cells with varied 3D geometries and cell densities developed towards the goal of scale-up for large animal pre-clinical studies. We explored multiple 15 × 15 mm ECT geometries using molds with rectangular internal staggered posts (mesh, ME), without posts (plain sheet, PS), or long parallel posts (multiple linear ...[more]
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