Ontology highlight
ABSTRACT:
SUBMITTER: Cai X
PROVIDER: S-EPMC5378051 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cai Xin X Xu Hui H Chen Zhijian J ZJ
Cold Spring Harbor perspectives in biology 20170403 4
The innate immune system relies on receptors that sense common signs of infection to trigger a robust host-defense response. Receptors such as RIG-I and NLRP3 activate downstream adaptors mitochondrial antiviral signaling (MAVS) and apoptosis-associated speck-like protein (ASC), respectively, to propagate immune and inflammatory signaling. Recent studies have indicated that both MAVS and ASC form functional prion-like polymers to propagate immune signaling. Here, we summarize the biochemical, ge ...[more]