Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC5378278 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Park Jae-Hyun JH Inoue Hiroyuki H Kato Taigo T Zewde Makda M Miyamoto Takashi T Matsuo Yo Y Salgia Ravi R Nakamura Yusuke Y
Cancer science 20170301 3
T-lymphokine-activated killer cell-originated protein kinase (TOPK) plays critical roles in cancer cell proliferation as well as maintenance of cancer stem cells (CSC). Small cell lung cancer (SCLC) has highly aggressive phenotype, reveals early spread to distant sites, and results in dismal prognosis with little effective treatment. In this study, we demonstrate that TOPK expression was highly upregulated in both SCLC cell lines and primary tumors. Similar to siRNA-mediated TOPK knockdown effec ...[more]