Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC5323188 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Song Xinhua X Yin Shutao S Zhang Enxiang E Fan Lihong L Ye Min M Zhang Yong Y Hu Hongbo H
Oncotarget 20161001 40
Glycycoumarin (GCM) is a major bioactive coumarin compound isolated from licorice and the anti-cancer activity of GCM has not been scientifically addressed. In the present study, we have tested the anti-liver cancer activity of GCM using both in vitro and in vivo models and found for the first time that GCM possesses a potent activity against liver cancer evidenced by cell growth inhibition and apoptosis induction in vitro and tumor reduction in vivo. Mechanistically, GCM was able to bind to and ...[more]