Ontology highlight
ABSTRACT:
SUBMITTER: Bui JK
PROVIDER: S-EPMC5378418 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Bui John K JK Sobolewski Michele D MD Keele Brandon F BF Spindler Jonathan J Musick Andrew A Wiegand Ann A Luke Brian T BT Shao Wei W Hughes Stephen H SH Coffin John M JM Kearney Mary F MF Mellors John W JW
PLoS pathogens 20170322 3
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for HIV persistence is clonal expansion of infected cells, but how often such clones carry replication-competent proviruses has been controversial. Here, we used single-genome sequencing to probe for ident ...[more]