Ontology highlight
ABSTRACT:
SUBMITTER: Abrahams MR
PROVIDER: S-EPMC7233356 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Abrahams Melissa-Rose MR Joseph Sarah B SB Garrett Nigel N Tyers Lynn L Moeser Matthew M Archin Nancie N Council Olivia D OD Matten David D Zhou Shuntai S Doolabh Deelan D Anthony Colin C Goonetilleke Nilu N Karim Salim Abdool SA Margolis David M DM Pond Sergei Kosakovsky SK Williamson Carolyn C Swanstrom Ronald R
Science translational medicine 20191001 513
Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the virus persists as a latent reservoir in resting CD4<sup>+</sup> T cells during therapy. This reservoir forms even when ART is initiated early after infection, but the dynamics of its formation are largely unknown. The viral reservoirs of individuals who initiate ART during chronic infection are generally larger and genetically more diverse than those of individuals who initiate therapy during acute in ...[more]