Ontology highlight
ABSTRACT:
SUBMITTER: Schoen C
PROVIDER: S-EPMC5378724 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Frontiers in physiology 20170404
Palatogenesis requires a precise spatiotemporal regulation of gene expression, which is controlled by an intricate network of transcription factors and their corresponding DNA motifs. Even minor perturbations of this network may cause cleft palate, the most common congenital craniofacial defect in humans. MicroRNAs (miRNAs), a class of small regulatory non-coding RNAs, have elicited strong interest as key regulators of embryological development, and as etiological factors in disease. MiRNAs func ...[more]