Ontology highlight
ABSTRACT:
SUBMITTER: Van der Borght K
PROVIDER: S-EPMC5379012 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Van der Borght Katrien K Scott Charlotte L CL Nindl Veronika V Bouché Ann A Martens Liesbet L Sichien Dorine D Van Moorleghem Justine J Vanheerswynghels Manon M De Prijck Sofie S Saeys Yvan Y Ludewig Burkhard B Gillebert Thierry T Guilliams Martin M Carmeliet Peter P Lambrecht Bart N BN
Cell reports 20170301 12
Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example of a sterile injury is myocardial infarction (MI). We hypothesized that tissue necrosis is an activator of dendritic cells (DCs), which control tolerance to self-antigens. DC subsets of a murine healthy heart consisted of IRF8-dependent conventi ...[more]