Myocardial infarction (MI) primes autoreactive T cells through activation of dendritic cells
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ABSTRACT: DC subsets of the murine healthy heart consisted of IRF8-dependent conventional (c)DC1, IRF4-dependent cDC2 and monocyte-derived DCs. In steady state, cardiac self-antigen α-myosin was presented in heart-draining mediastinal lymph node (mLN) by cDC1s, driving the proliferation of antigen-specific CD4+ TCR-M T cells, and their differentiation into Tregs. Following MI, all DC subsets infiltrated the heart, while only cDCs migrated to the mLN. Here, cDC2s induced TCR-M proliferation and differentiation into IL-17/IFNγ producing effector cells. Thus, cardiac specific autoreactive T cells get activated by mature DCs following myocardial infarction.
ORGANISM(S): Mus musculus
PROVIDER: GSE94949 | GEO | 2017/03/15
SECONDARY ACCESSION(S): PRJNA374892
REPOSITORIES: GEO
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