Understanding the conformational motions of RCK gating rings.
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ABSTRACT:
SUBMITTER: Giraldez T
PROVIDER: S-EPMC5379921 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Understanding the conformational motions of RCK gating rings.
Giraldez Teresa T Rothberg Brad S BS
The Journal of general physiology 20170228 4
Regulator of conduction of K<sup>+</sup> (RCK) domains are ubiquitous regulators of channel and transporter activity in prokaryotes and eukaryotes. In humans, RCK domains form an integral component of large-conductance calcium-activated K channels (BK channels), key modulators of nerve, muscle, and endocrine cell function. In this review, we explore how the study of RCK domains in bacterial and human channels has contributed to our understanding of the structural basis of channel function. This ...[more]
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