Ontology highlight
ABSTRACT:
SUBMITTER: Marwaha R
PROVIDER: S-EPMC5379943 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Marwaha Rituraj R Arya Subhash B SB Jagga Divya D Kaur Harmeet H Tuli Amit A Sharma Mahak M
The Journal of cell biology 20170321 4
Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. However, the potential cross talk between these two GTPases is unclear. Here, we show that the Rab7 effector PLEKHM1 simultaneously binds Rab7 and Arl8b, bringing about clustering and fusion of late endosomes and lysosomes. We show that the N-terminal RUN domain of PLEKHM1 is necessary and ...[more]