Ontology highlight
ABSTRACT:
SUBMITTER: Feng Z
PROVIDER: S-EPMC5380121 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170313 11
Cancer cells differ from normal cells in both gain of functions (i.e., upregulation) and loss of functions (i.e., downregulation). While it is common to suppress gain of function for chemotherapy, it remains challenging to target downregulation in cancer cells. Here we show the combination of enzyme-instructed assembly and disassembly to target downregulation in cancer cells by designing peptidic precursors as the substrates of both carboxylesterases (CESs) and alkaline phosphatases (ALPs). The ...[more]