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Pulse pressure-dependent cerebrovascular eNOS regulation in mice.


ABSTRACT: Arterial blood pressure is oscillatory; whether pulse pressure (PP) regulates cerebral artery myogenic tone (MT) and endothelial function is currently unknown. To test the impact of PP on MT and dilation to flow (FMD) or to acetylcholine (Ach), isolated pressurized mouse posterior cerebral arteries were subjected to either static pressure (SP) or a physiological PP (amplitude: 30?mm Hg; frequency: 550 bpm). Under PP, MT was significantly higher than in SP conditions ( p?2, FMD was lower ( p?

SUBMITTER: Raignault A 

PROVIDER: S-EPMC5381440 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Pulse pressure-dependent cerebrovascular eNOS regulation in mice.

Raignault Adeline A   Bolduc Virginie V   Lesage Frédéric F   Thorin Eric E  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160721 2


Arterial blood pressure is oscillatory; whether pulse pressure (PP) regulates cerebral artery myogenic tone (MT) and endothelial function is currently unknown. To test the impact of PP on MT and dilation to flow (FMD) or to acetylcholine (Ach), isolated pressurized mouse posterior cerebral arteries were subjected to either static pressure (SP) or a physiological PP (amplitude: 30 mm Hg; frequency: 550 bpm). Under PP, MT was significantly higher than in SP conditions ( p < 0.05) and was not affec  ...[more]

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