Ontology highlight
ABSTRACT:
SUBMITTER: Jorgensen LM
PROVIDER: S-EPMC5381441 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Jørgensen Louise M LM Weikop Pia P Villadsen Jonas J Visnapuu Tanel T Ettrup Anders A Hansen Hanne D HD Baandrup Anders O AO Andersen Flemming L FL Bjarkam Carsten R CR Thomsen Carsten C Jespersen Bo B Knudsen Gitte M GM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20160720 2
Positron emission tomography (PET) can, when used with appropriate radioligands, non-invasively generate temporal and spatial information about acute changes in brain neurotransmitter systems. We for the first time evaluate the novel 5-HT<sub>2A</sub> receptor agonist PET radioligand, [<sup>11</sup>C]Cimbi-36, for its sensitivity to detect changes in endogenous cerebral 5-HT levels, as induced by different pharmacological challenges. To enable a direct translation of PET imaging data to changes ...[more]