X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.
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ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5381722 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.
Yang H H Du Bois D R DR Ziller J W JW Nowick J S JS
Chemical communications (Cambridge, England) 20170201 18
The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity. ...[more]
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