Ontology highlight
ABSTRACT:
SUBMITTER: Chen KH
PROVIDER: S-EPMC6361391 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Chen K H KH Le S P SP Han X X Frias J M JM Nowick J S JS
Chemical communications (Cambridge, England) 20171001 82
An alanine scan of Lys<sub>10</sub>-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobactin analogues is observed. ...[more]