Ontology highlight
ABSTRACT:
SUBMITTER: Shirakawa J
PROVIDER: S-EPMC5382039 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Shirakawa Jun J Fernandez Megan M Takatani Tomozumi T El Ouaamari Abdelfattah A Jungtrakoon Prapaporn P Okawa Erin R ER Zhang Wei W Yi Peng P Doria Alessandro A Kulkarni Rohit N RN
Cell metabolism 20170309 4
Investigation of cell-cycle kinetics in mammalian pancreatic β cells has mostly focused on transition from the quiescent (G0) to G1 phase. Here, we report that centromere protein A (CENP-A), which is required for chromosome segregation during the M-phase, is necessary for adaptive β cell proliferation. Receptor-mediated insulin signaling promotes DNA-binding activity of FoxM1 to regulate expression of CENP-A and polo-like kinase-1 (PLK1) by modulating cyclin-dependent kinase-1/2. CENP-A depositi ...[more]