Ontology highlight
ABSTRACT:
SUBMITTER: Jiang M
PROVIDER: S-EPMC8237857 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Jiang Mengxue M Kuang Zhijian Z He Yaohui Y Cao Yin Y Yu Tingyan T Cheng Jidong J Liu Wen W Wang Wei W
Frontiers in endocrinology 20210614
In diabetes mellitus, death of β cell in the pancreas occurs throughout the development of the disease, with loss of insulin production. The maintenance of β cell number is essential to maintaining normoglycemia. SNAPIN has been found to regulate insulin secretion, but whether it induces β cell proliferation remains to be elucidated. This study aimed to explore the physiological roles of SNAPIN in β cell proliferation. SNAPIN expression increases with the age of mice and SNAPIN is down-regulated ...[more]