Ontology highlight
ABSTRACT:
SUBMITTER: Kannan A
PROVIDER: S-EPMC5382706 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kannan Anbarasu A Hertweck Kate L KL Philley Julie V JV Wells Robert B RB Dasgupta Santanu S
Scientific reports 20170406
Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in t ...[more]