Unknown

Dataset Information

0

Pulmonary Nontuberculous Mycobacteria-Associated Deaths, Ontario, Canada, 2001-2013.


ABSTRACT: Survival implications of nontuberculous mycobacterial pulmonary disease (NTM-PD) and NTM pulmonary isolation without disease (NTM-PI) are unclear. To study deaths associated with NTM-PD and NTM-PI and differences in survival between them, we conducted a population-based cohort study of persons with microbiologically defined NTM-PD or NTM-PI diagnosed during 2001-2013 in Ontario, Canada. We used propensity score matching and Cox proportional hazards models to compare survival. Among 9,681 NTM-PD patients and 10,936 NTM-PI patients, 87% and 91%, respectively, were successfully matched with unexposed controls. Both NTM-PD and NTM-PI were associated with higher rates of death for all species combined and for most individual species. Compared with NTM-PI, NTM-PD was associated with higher death rates for all species combined, Mycobacterium avium complex, and M. xenopi. NTM-PD and NTM-PI were significantly associated with death, NTM-PD more so than NTM-PI.

SUBMITTER: Marras TK 

PROVIDER: S-EPMC5382758 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7454113 | biostudies-literature
| S-EPMC10310396 | biostudies-literature
| S-EPMC6590764 | biostudies-literature
| S-EPMC4766895 | biostudies-literature
| PRJNA532547 | ENA
| PRJNA779755 | ENA
| S-EPMC10326639 | biostudies-literature
| S-EPMC9156420 | biostudies-literature
| S-EPMC6004863 | biostudies-literature
| S-EPMC4111185 | biostudies-literature