Dataset Information
N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate.
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ABSTRACT:
SUBMITTER: Chen XY
PROVIDER: S-EPMC5384455 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate.
Chemical science 20161109 3
The N-heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindole and enals was developed, giving the corresponding spirocyclic oxindole-γ-lactones in good yields with high to excellent diastereo- and enantioselectivities. The challenging aliphatic enals worked effectively using this strategy. The oxidative cross coupling of homoenolate and enolate <i>via</i> single electron transfer was proposed as the key step for the reaction. ...[more]