Ontology highlight
ABSTRACT:
SUBMITTER: Che L
PROVIDER: S-EPMC5384589 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Che Li L Pilo Maria G MG Cigliano Antonio A Latte Gavinella G Simile Maria M MM Ribback Silvia S Dombrowski Frank F Evert Matthias M Chen Xin X Calvisi Diego F DF
Cell cycle (Georgetown, Tex.) 20170124 6
Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an aggressive cancer type with limited treatment options. Cumulating evidence underlines a crucial role of aberrant lipid biosynthesis (a process known as de novo lipogenesis) along carcinogenesis. Previous studies showed that suppression of fatty acid synthase (FASN), the major enzyme responsible for de novo lipogenesis, is highly detrimental for the in vitro growth of HCC cell lines. To assess whether de novo lipo ...[more]