Ontology highlight
ABSTRACT:
SUBMITTER: Bollu LR
PROVIDER: S-EPMC4741504 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Bollu Lakshmi Reddy LR Katreddy Rajashekhara Reddy RR Blessing Alicia Marie AM Pham Nguyen N Zheng Baohui B Wu Xu X Weihua Zhang Z
Oncotarget 20151001 33
Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR exists in certain cancer cells, and the underlying mechanism remains to be defined. In this study, using PC3 and A549 cells as a model, we have found that, in the absence of extracellular ligands, a subpopulation of EGFR is constitutively active, which is needed for maintaining ...[more]