Ontology highlight
ABSTRACT:
SUBMITTER: Keric N
PROVIDER: S-EPMC5385248 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Keric Naureen N Masomi-Bornwasser Julia J Müller-Werkmeister Hendrik H Kantelhardt Sven Rainer SR König Jochem J Kempski Oliver O Giese Alf A
BioMed research international 20170326
Hematoma lysis with recombinant tissue plasminogen activator (rtPA) has emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH). Optimal dose and schedule are still unclear. The aim of this study was to create a reliable in vitro blood clot model for investigation of optimal drug dose and timing. An in vitro clot model was established, using 25 mL and 50 mL of human blood. Catheters were placed into the clots and three groups, using intraclot application of rtPA, placebo ...[more]