Ontology highlight
ABSTRACT:
SUBMITTER: Cayo MA
PROVIDER: S-EPMC5385853 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cayo Max A MA Mallanna Sunil K SK Di Furio Francesca F Jing Ran R Tolliver Lauren B LB Bures Matthew M Urick Amanda A Noto Fallon K FK Pashos Evanthia E EE Greseth Matthew D MD Czarnecki Maciej M Traktman Paula P Yang Wenli W Morrisey Edward E EE Grompe Markus M Rader Daniel J DJ Duncan Stephen A SA
Cell stem cell 20170401 4
Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack of models. However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs). Here, we have used hepatocyte-like cells generated from homozygous familial hypercholesterolemia (hoFH) iPSCs to identify drugs that can potentially be repurposed to lower serum LDL-C. We found that cardiac glycosides reduce the production of apolipoprotein B (apoB) fro ...[more]