Ontology highlight
ABSTRACT:
SUBMITTER: Peng F
PROVIDER: S-EPMC5386357 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Peng Fei F Li Ting-Ting TT Wang Kai-Li KL Xiao Guo-Qing GQ Wang Ju-Hong JH Zhao Hai-Dong HD Kang Zhi-Jie ZJ Fan Wen-Jun WJ Zhu Li-Li LL Li Mei M Cui Bai B Zheng Fei-Meng FM Wang Hong-Jiang HJ Lam Eric W-F EW Wang Bo B Xu Jie J Liu Quentin Q
Cell death & disease 20170119 1
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inh ...[more]